What is the History of Pandemics

Pandemics have long been a part of human history. This includes various disease that spread globally and have, in many different periods, created a large-scale population reduction. For ancient periods, pandemics were often conflated with plagues. While the recent COVID-19 pandemic is of concern, many other pandemics have caused far worse social disruption and destruction.

Earliest Evidence for Pandemics

Some of the earliest recorded epidemics may appear by the mid-2nd millennium BCE. In Mesopotamia, recordings of plague are made in the Old Babylonian period (1800-1600 BCE), which could have been a pandemic that had started in Asia or spread in Asia. By around 1400 BCE, the Hittites mention plague was spread through their country and that they had asked the gods to spread the disease to their enemies, taking it away. In fact, by 1200 BCE, a great collapse of states occurred, including the the Hittites, and along the eastern Mediterranean, with the Mycenaean Greeks collapsing as well. Texts indicate that great waves of invasions occurred that caused this collapse. However, it is likely something else triggered While nobody knows for sure what triggered these mass migrations and invasions, one possibility is a chain reaction of events across Eurasia led to migrations that pushed groups to take risky invasions of areas such as southeast Europe and Mediterranean region. Pestilence, plagues, and global pandemics have been leading reasons as to what caused these migrations and invasions to occur. The events were so pronounced that for 200 years, few written records were produced and has been called one of the earliest great 'Dark Ages' due to the scale of impact these events had on established complex societies around the Mediterranean region.

One relatively well-known early pandemic was a pandemic that fatally weakened the power of Athens in the 5th century BCE. From around 430-426 BCE, historians believe typhoid likely became widespread in Athens, killing not only many of its citizens but also weakening its army. This led Athens to lose power to its competitor city-states, particularly Sparta, in the Peloponnesian War. Athens would not regain any significant influence for generations, as the population had to recover from the devastation of the outbreak. While other states may have been affected by this outbreak, the death rates were so high and sudden that in a way it likely limited the impact of the outbreak mainly to Athens. This possibly explains why it was mainly Athens that weakened and not other states. Cholera may have been the most common forms of epidemics that could have transformed into global or regional pandemics. In fact, cholera would remain among the most frequently reoccurring epidemic and pandemic until the 20th century, by then improved sanitation and drinking water had reduced its effects.

Late Antiquity and Medieval Pandemics

The pace of knowledge on pandemics increased in Late Antiquity. One of the first recorded in this period was the Antonine Plague in 165-180 CE, likely caused by small pox brought back from the Middle East or elsewhere in the Roman empire, where the pandemic killed perhaps tens of thousands in the capital. Millions may have died globally form this devastating pandemic. One of the first large-scale killers comparable in scale to the Black Death was the Plague of Justinian, which likely started around 541 CE. A likely killer was an early form of the bacterial bubonic plague, similar to the Black Death plague in the 14th century. This was also one of the first to likely span every Old World major city. It is estimated that Constantinople lost 40% of its population with up to half of Europe's population being affected or killed by this plague. In fact, this devastation likely kept Europe in a prolonged Dark Age, where few recorded historical records were produced because of the very low population levels in the region. By the 8th century, only small towns existed through most of Europe and the population was still very low compared to its level seen in the Late Roman period in the 4th century. Similarly, perhaps the same or similar plagues weakened the Sasanian Empire in the 7th century, which led to that state becoming weak and eventually it collapsed during the Islamic invasion in 651. The Sasanian were a very urban society, making them vulnerable for disease to spread rapidly through their cities. Overall, no disease would approach the scale of the Justinian Plague until the Black Death. Recent work has suggested that plague started in Central Asia before spreading to the Byzantine Empire, the Near East, and then Europe. the Byzantine Emperor Justinian did, in fact, contract the plague but he managed to survive it.

A contender for the most devastating pandemic in history is the Black Death between 1346–1353. While it does seem that pandemics did greatly shape the course of history in earlier periods, such as the Justinian Plague and the typhoid that likely weakened Athens, few events shaped global history as the Black Death. The Black Death weakened many states, including those across the Middle East, China, India, and Europe. Some regions did not recover more quickly, while others were never able to recover completely until the past century, such as the Middle East. For Europe, it took over 200 years for the population to approach levels of the 14th century. The remnants of this plague in fact have been found to reoccur or break out in various regions in the Old World, including in Central Asia where it likely originated, until the early 20th century.